Clostridial disease. Fatal disease of young cattle caused by one of the Clostridium bacteria. Blackleg is the most well known, but other clostridial diseases are also highly fatal. Currently, the most commonly used clostridial vaccination in cattle is the 7-way type, which protects against Clostridium chauveoi (blackleg), Clostridium septicumClostridium sordelli (malignant edema), Clostridium novyi (black disease), and three types of Clostridium perfringens (enterotoxemia).

Calf vaccination is an important part of every herd health program. An effective vaccination protocol can be developed to fit most operation and management approaches. This guide describes three calf vaccination approaches that have been successfully implemented in cow-calf operations in New Mexico. However, producers should consult with their local veterinarian to design a vaccination program that fits their particular operation.


Clostridial vaccines (often referred to as “7-way,” “8-way” or “9-way” vaccines) are some of the most frequently used products in beef cattle production today. While they’re almost automatically included in most beef producers’ preventive medicine programs, many producers may not have taken time to consider the features and attributes of the various clostridial vaccines available today: One Shot Ultra® 7 is effective for vaccination of healthy cattle against disease caused by Clostridium chauvoeiCl. septicumCl. novyiCl. sordelliiCl. perfringens Types B, C and D, and respiratory disease caused by Mannheimia haemolytica Type A1.

Advantages of 7 Way Clostridial Vaccine

  • Proven protection against clostridial diseases
  • Available as both a 3-way or 7-way clostridial, as well as in a combination of 7-way clostridia and Moraxella bovis (pinkeye)
  • Unique DD-2™ adjuvant stimulates a strong immune response
  • BQA compliant for both low dose and subcutaneous guidelines 


Recommended for the vaccination of healthy, susceptible cattle and sheep as an aid in the reduction of diseases caused by Clostridium chauvoei, Cl. septicum, Cl. novyi, Cl. sordellii, Cl. perfringens Types C & D. Although Clostridium perfringens Type B is not a significant problem in the U.S.A., immunity may be provided against the beta and epsilon toxins elaborated by Clostridium perfringens Type B. This immunity is derived from the combination of Type C (beta) and Type D (epsilon) fractions.

Routes of administration

Clostridial vaccines generally require subcutaneous (under the skin) administration. These vaccines, like all others, should be given in the neck according to Beef Quality Assurance (BQA) guidelines. Should a dose of clostridial vaccine be given in the muscle (intramuscularly) instead, swelling and pain at the injection site will be more likely. In addition, the effect on the immune response of a clostridial vaccine given intramuscularly is largely unknown; the vaccine company can confirm the product’s effects when given according to label directions but not otherwise.

Incidentally, as anyone who has inadvertently stuck themselves with a syringe containing clostridial vaccine can attest, the result of a needle stick is usually a great deal of pain and swelling at the site of entry. This reaction is directed more toward the adjuvant (chemical compound added to the vaccine to enhance the immune response) than the clostridial antigens. The swelling and pain typically subside after a while; ice and pain relievers can help. Should swelling persist or worsen over a period of one or two days, a health professional should be consulted, as this may be an indication of infection.

Mode of action

The freeze-dried component is a preparation of inactivated whole cultures of M. haemolytica propagated to increase the production of leukotoxin and capsular and cell-associated antigens. The liquid component consists of killed, standardized cultures of Cl. chauvoei, Cl. septicum, Cl. novyi, Cl. sordellii, and Cl. perfringens types C and D, with a special, water-soluble adjuvant (Stimugen®) to enhance the immune response.

Prices of 7 Way Clostridial Vaccine

$22.79 – $59.99

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