The most notable of rabbit diseases is coccidiosis which causes massive economic losses in rabbit production Coccidiosis results in high mortality and morbidity especially among weaner rabbits Thirteen Eimeria species with varied pathogenicity are known to cause coccidiosis in rabbits [1]. Two forms of coccidiosis exist in rabbits (Oryctolagus cuniculus): intestinal coccidiosis where the invading protozoan target epithelial cells of different regions of the intestines resulting in moderate to severe damage depending on the virulence of the species] and hepatic coccidiosis where the predilection site of E. stiedae is the liver Though most hepatic infections are mild, severe cases can result in progressive emaciation, hepatomegaly with slightly raised yellowish-white nodules, or cords develop which later on tend to coalesce thereby interfering with liver function
There are up to 25 different species that can cause this condition in the rabbit. Although many rabbits can carry the protozoa without symptoms, in some cases, the parasite may cause trauma and illness for the pet. The spore enters the intestinal wall of the rabbit following ingestion, this is often through food or water sources infected with fecal matter containing oocytes.
Description
Amprolium is a coccidiostat (antiprotozoal) used for the treatment and prevention of coccidiosis in calves, sheep, goats, chickens (broilers and breeders) and other fowl such as turkeys, with activity against Eimeria spp., especially Eimeria tenella and Eimeria necatrix. It is a thiamine (vitamin B1) analogue and its pharmacological effect relies on competitive inhibition of thiamine uptake. Amprolium competitively inhibits the active transport of thiamine in isolated second-generation schizonts of Eimeria spp. and in host intestinal cells. Upon ingestion of amprolium, the coccidia experience thiamine deficiency and starve from malnutrition.
Indications:
Amprolium 20% Oral is a concentrated liquid containing amprolium, to be used in drinking water of poultry, calves, lambs, young goats, cattle and sheep. It is used as a prophylactic or therapeutic agent against Eimeria infections in poultry, especially E. tenella, E. necatrix, E. acervulina and E. praecox. It is effective against other protozoal infections like Histomoniasis (Blackhead) in turkeys and poultry; against coccidiosis in calves, sheep, goats and pigs; against amoebiasis in various species.
Side effects
Overdosage of amprolium can suppress weight gain in broilers and cause polyneuritis. Long-term administration of amprolium in high doses may result in thiamine (vitamin B1) deficiency in the host. To treat amprolium overdose, thiamine should be administered parenterally or orally.
Dosage/administration:
For oral administration via feed or drinking water.
- Poultry : 125 – 200 ml per 100 litres of drinking water during 5 – 7 days, followed by 30 ml per 100 litres of drinking water during 1 or 2 weeks. (During treatment, only medicated drinking
water should be administered.) - Calves, lambs, kids, pigs : 4 ml per 20 kg bodyweight as drench during 1 – 2 days, followed by 10 litres per 1,000 litres of drinking water during 3 weeks.
- Cattle, sheep : 4 ml per 20 kg bodyweight during 5 days.
Mixed with feed, the product should be used immediately. Medicated drinking water should be used within 24 hours.
If no improvement is noted within 3 days, evaluate the symptoms to determine the presence of other diseases. Follow the instructions of your veterinarian or poultry pathologist.
Withdrawal times:
Meat : 3 days
Milk : 3 days
Prices of Amprolium For Rabbits
$17.80 – $24.99