Anipryl (selegiline), also known as L-Deprenyl, is a monoamine oxidase inhibitor (MAOI) that treats Cushing’s Disease and Canine Cognitive Dysfunction Syndrome (senility). Anipryl requires a prescription from your veterinarian. Selegiline Capsules for Dogs may be used for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and uncomplicated canine pituitary dependent hyperadrenocorticism (PDH). Selegiline Capsules contain selegiline HCl. The recommended dosage is 0.5 to 1 mg/kg once daily. Selegiline HCl.


Anipryl is an oral tablet prescribed by veterinarians to control the clinical signs of canine cognitive dysfunction syndrome (CDS) and of uncomplicated pituitary-dependent Addison’s Disease (PDH). Since this medication is a selective monoamine oxidase -B inhibitor, it may enhance catecholamine neuroactivity and increase dopamine levels in dogs. Unlike other prescription medications, Anipryl does not require laboratory tests for treatment and it can be given with your canine companion’s favorite food.

Features of Anipryl For Dogs

Anipryl is a medication used to treat cognitive dysfunction and senility in older animals.

  • – Used to treat clinical signs of Canine Cognitive Dysfunction Syndrome
  • – Only FDA-approved drug for canine senility
  • – Used for some types of Cushing’s disease caused by a pituitary tumor in dogs
  • – Approximately 70% of dogs with cognitive dysfunction respond to this medication after one month of treatment

Uses/benefits of Anipryl For Dogs

Anipryl tablets are indicated for the control of clinical signs associated with canine cognitive dysfunction syndrome (CDS) and control of clinical signs associated with uncomplicated canine pituitary-dependent hyperadrenocorticism (PDH).Possible Side Effects

Contact your veterinarian if your dog experiences restlessness/agitation, vomiting, disorientation, diarrhea, diminished hearing, possible drug interaction (weakness, confusion, incoordination and “seizure like” activity while being treated concurrently with metronidazole, prednisone, and trimethoprim sulfa), increase in destructive behavior in a dog with separation anxiety, anorexia, anemia, stiffness and polydipsia.

Dosage and Administration

CDS:The recommended dosage for oral administration for the control of clinical signs associated with CDS is 0.5-1.0 mg/kg once daily, preferably administered in the morning. Initially, dogs should be dosed to the nearest whole tablet. Adjustments should then be made based on response and tolerance to the drug. PDH:The recommended dosage for the control of clinical signs associated with canine PDH is 1.0 mg/kg once daily, preferably administered in the morning. If no improvement is observed after 2 months of therapy, dosage may be increased to a maximum of 2.0 mg/kg once daily. If no improvement is seen after 1 month at the higher dose or if at any time clinical signs progress, the dog should be re-evaluated. In dogs whose clinical signs of PDH progress despite Anipryl therapy in the absence of concurrent disease, alternate therapy should be considered.

Dogs should be monitored closely for possible adverse events associated with any increase in dose.

Clinical Use of Anipryl in CDS:CDS is an age-related deterioration of cognitive abilities characterized by behavioral changes not wholly attributable to a general medical condition such as neoplasia, infection, or organ failure. CDS is typified by multiple cognitive impairments which affect the dog’s function. In clinical trials, the observed behavioral changes associated with CDS in older dogs included: disorientation, decreased activity level, abnormal sleep/wake cycles, loss of housetraining, decreased or altered responsiveness to family members, and decreased or altered greeting behavior. In clinical trials, Anipryl was shown to be effective in controlling clinical signs associated with CDS. After 4 weeks of treatment, dogs treated with Anipryl showed significant improvement when compared to placebo-treated controls in sleeping patterns, housetraining, and activity level. Some dogs showed increased improvement up to 3 months, however, onset, duration and magnitude of response varied with individual dogs.

Side Effects of Anipryl For Dogs

As with most pet medications there are possible side effects with Anipryl for dogs, that is why, it is ideal to follow your veterinarian’s instructions precisely.

Also, immediately report any signs of potential complications including:

  • Vomiting
  • Diarrhea
  • Disorientation
  • Seizures
  • Hyperactivity
  • Hair loss
  • Shaking


Dog could develop dizziness or drowsiness, nausea, abdominal pain or diarrhea, insomnia, mild confusion, agitation or anxiety or dry mouth. Consult your Veterinarian if any symptoms become extreme or bothersome to your dog. Anipryl should not be administered if pet is taking meperidine and should not be given with antidepressants. Advise Veterinarian about any other medical conditions or if your pet is pregnant or lactating.

Prices of Anipryl For Dogs

$52.95 – $99.02

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