Apoquel® is the brand name of oclacitinib, an FDA approved immune suppressant drug in the Janus Kinase (JAK) inhibitor class made by Zoetis. This drug inhibits primarily JAK-1 and -3 signaling that would normally occur when a cytokine binds to a receptor on the surface of the cell. This includes blocking the effects of inflammatory cytokines released from activated lymphocytes (IL-2, -4, -6, -13) as well as IL-31, a cytokine directly involved in the sensation of itch. JAK signaling is important to the function of the bone marrow as well. Apoquel works differently than steroids, antihistamines, or cyclosporine.
Apoquel works rapidly, usually within 24 hours, to diminish itching. It is very rare to have GI upsets with Apoquel like we can see with cyclosporine. The antipruritic effects of the Apoquel wear off quickly, within 12-24 hours, so the medication needs to be given daily in most cases.
Description
Apoquel is an oral tablet that works differently than other allergy medications. It goes straight to the source to help relieve itch and inflammation at its core—addressing the underlying cause of irritation and soothing allergic reactions. It starts to relieve those unpleasant symptoms within 4 hours, and effectively controls itching within 24. Apoquel is ideal for both short or long-term treatment and can help to offer relief without many of the side effects associated with steroids. Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.
Features of Apoquel For Dogs
Apoquel is used to relieve itching and inflammation caused by allergic skin disease (atopy, atopic dermatitis) in dogs. The active ingredient is oclacitinib
- – Relieves itchy skin caused by allergies
- – Starts to relieve itching within 4 hours.
- – Effectively controls itching within 24 hours.
- – Short-term or long-term treatment without many of the side effects associated with steroids.
Precautions
Do not use Apoquel in dogs less than 12 months of age or those with serious infections. APOQUEL may increase the chances of developing serious infections and may cause existing parasitic skin infestations or pre-existing cancers to get worse. APOQUEL has not been tested in dogs receiving some medications including some commonly used to treat skin conditions such as corticosteroids and cyclosporine. Apoquel is not for use in breeding dogs or pregnant or lactating females. Dogs taking Apoquel should be monitored for the development of infections.
Dosage and Administration
The dose of APOQUEL (oclacitinib maleate) tablets is 0.18 to 0.27 mg oclacitinib/lb (0.4 to 0.6 mg oclacitinib/kg) body weight, administered orally, twice daily for up to 14 days, and then administered once daily for maintenance therapy. APOQUEL may be administered with or without food.
| Weight Range (in lb) | Weight Range (in Kg) | Number of Tablets to be Administered | ||||
| Low | High | Low | High | 3.6 mg Tablets | 5.4 mg Tablets | 16 mg Tablets |
| 6.6 | 9.9 | 3.0 | 4.4 | 0.5 | – | – |
| 10.0 | 14.9 | 4.5 | 5.9 | – | 0.5 | – |
| 15.0 | 19.9 | 6.0 | 8.9 | 1 | – | – |
| 20.0 | 29.9 | 9.0 | 13.4 | – | 1 | – |
| 30.0 | 44.9 | 13.5 | 19.9 | – | – | 0.5 |
| 45.0 | 59.9 | 20.0 | 26.9 | – | 2 | – |
| 60.0 | 89.9 | 27.0 | 39.9 | – | – | 1 |
| 90.0 | 129.9 | 40.0 | 54.9 | – | – | 1.5 |
| 130.0 | 175.9 | 55.0 | 80.0 | – | – | 2 |
Prices of Apoquel For Dogs
$167.99 – $228.99