Cefpodoxime For Dogs

Cefpodoxime (brand names Simplicef® and Vantin®) is a third-generation cephalosporin antibiotic used to treat skin infections in dogs. The bacteria that are susceptible to cefpodoxime include certain Staphylococcus and Pasteurella species, Streptococcus canisE. coli, and certain bacteria causing urinary tract infections.

The use of cefpodoxime in cats is off label or extra-label and is also off-label for the treatment of urinary tract infections in dogs. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully.


Cefpodoxime is more commonly known under the brand names Simplicef and Vantin. It is a type of third-generation antibiotic called Cephalosporin. The third generation only means that it is partly synthetic, having been developed from the first types of antibiotics. Cefpodoxime is used most commonly for treating bacterial infections in dogs. However, it can also be used just as well for cats, although it is not often the first choice. Cefpodoxime is a broad spectrum of antibiotics.

Being a broad-spectrum antibiotic means that it can affect both gram-positive and gram-negative bacteria. It works by affecting the cell wall of the bacteria. Effectively, the antibiotics make holes in the cell wall. This kills the bacteria, meaning Cefpodoxime is bactericidal. 

Side effect

Like any medication, cefpodoxime can cause side effects in dogs. Fortunately, these side effects are rare. A small percentage of dogs taking this medication will experience gastrointestinal upset. This effect can typically be minimized by giving cefpodoxime with a full meal. In very rare circumstances, dogs may experience an allergic reaction to cefpodoxime that may vary from mild to severe.

Cefpodoxime side effects for dogs may include: 

  • Vomiting
  • Diarrhea
  • Decreased appetite
  • Hives 
  • Shortness of breath 
  • Facial swelling


Do not administer to pets that are allergic to cephalosporins or penicillins unless directed by your veterinarian and do not use in pregnant or lactating dogs. Use caution when giving to pets with seizures, epilepsy, or kidney disease and if your pet has any allergic reactions to the medication, contact your veterinarian immediately.

Dosage And Administration

Dose range: The dose range of Cefpodoxime Proxetil Tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular patient must take into consideration such factors as the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the patient’s host-defense mechanisms. Obtain a sample of the pathogenic organism for culture and sensitivity testing prior to beginning antimicrobial therapy. Once results become available, continue with appropriate therapy.

Duration: Cefpodoxime Proxetil Tablets should be administered once daily for 5-7 days or for 2-3 days beyond the cessation of clinical signs, up to a maximum of 28 days. Treatment of acute infections should not be continued for more than 3-4 days if no response to therapy is seen.

Dosing Charts: For daily oral administration of Cefpodoxime Proxetil Tablets at 5 mg/kg (Table 1) and 10 mg/kg (Table 2).

Dosefor Cefpodoxime Proxetil Tablets at 5 mg/kg Total Daily Dosage

Weight of Dog (lbs)
Daily Dose22446688132
No. of 100 mg tablets0.511.5 1
No. of 200 mg tablets   11
Weight of Dog (kgs)
Daily Dose1020304060
No. of 100 mg tablets0.511.5 1
No. of 200 mg tablets   11

Prices of Cefpodoxime For Dogs

$14.39 – $41.99

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