Ciprofloxacin, a new carboxyquinoline antimicrobial agent, was compared with tobramycin in the treatment of chronic osteomyelitis due to Pseudomonas aeruginosa in rabbits. Treatment with tobramycin for four weeks was ineffective (94% had positive bone cultures). In contrast, ciprofloxacin administered for four weeks sterilized the bones of all but one (94%) of 18 treated rabbits. Treatment with ciprofloxacin for two weeks was less effective than treatment for four weeks but was more effective than either treatment with tobramycin or no therapy. Two of 10 isolates from rabbits treated with ciprofloxacin for two weeks were susceptible to MICs of ciprofloxacin that were 16-and fourfold greater than the MIC for the parent strain; the other eight isolates remained sensitive to ciprofloxacin with MICs equivalent to that of the parent strain.
Features of Ciprofloxacin For Rabbits
Enrofloxacin, like other fluoroquinolones, is used to treat susceptible bacteria in a variety of species. Treatment has included infections of skin and soft tissue, urinary tract infections in dogs and cats, Chlamydophila felis infections in cats, and ulcerative colitis caused by Escherichia coli in dogs. Enrofloxacin has been shown effective for treating Rickettsia infections in dogs. However, it is not effective for treating Ehrlichia (see Doxycycline).
In horses, it has been used for a variety of soft tissue infections and respiratory infections, although this use is based primarily on anecdotal experience. Enrofloxacin is approved for the treatment and control of swine respiratory disease (SRD) associated with Actinobacillus pleuropneumoniae, Pasteurella multocida, Haemophilus parasuis, and Streptococcus suis. It is also approved for treatment of bovine respiratory disease (BRD) associated with Mannheimia haemolytica, P. multocida, and Haemophilus somni (previously Haemophilus somnus). Enrofloxacin is also used in most exotic animal species because of its safety and activity against a wide variety of pathogens.
Uses/benefits of Ciprofloxacin For Rabbits
Enrofloxacin is a fluoroquinolone antibacterial drug. It is bactericidal with a broad spectrum of activity. Its mechanism of action inhibits DNA gyrase, thus inhibiting both DNA and RNA synthesis. Sensitive bacteria include Staphylococcus, Escherichia coli, Proteus, Klebsiella, and Pasteurella. Pseudomonas is moderately susceptible but requires higher dosages. In some species, enrofloxacin is partially metabolized to ciprofloxacin.
Prices of Ciprofloxacin For Rabbits
$22.90 – $48.95