When veterinarians prescribe Prozac (fluoxetine as generic) for dogs, it’s the same medication you would receive from your doctor for a similar issue—just in a different dosage. It’s a selective serotonin reuptake inhibitor (SSRI), meaning it blocks your body from reabsorbing serotonin. When levels of this neurotransmitter are higher in the brain, it’s thought to improve mood. Does your dog need anti-anxiety medication?

Before prescribing anti-anxiety meds, your vet needs to rule out a medical cause. Dog anxiety can be triggered by internal issues such as irritability caused by allergies or even pain caused by osteoarthritis. Once an underlying condition is ruled out, a veterinary behaviorist will assess your dog’s social and environmental history and anxiety episodes. “It’s not really always about figuring out the ‘why,’ but how to move forward,” Dr. Pike says. A diagnosis—such as fear-based aggression with people and dogs—will be followed by a prognosis. A treatment plan including medications and behavioral modification will also be made.  


Fluoxetine is an antidepressant and anti-anxiety drug for dogs that is often referred to by the brand names Reconcile or Prozac — the human form of the drug. It works by inhibiting reuptake of the neurotransmitter serotonin. The drug has several uses for treating conditions in dogs such as behavioral problems, separation anxiety, fear, and aggression. This medication is meant to be prescribed alongside behavior modification training. As a dog responds to behavior modification, dosage of the drug is weaned away. Fluoxetine is for short-term use until a condition is manageable without it. There are some side effects that can be harmful to dogs, and the drug can react badly with other medication.

Here’s what you should know about the uses, dosage, and side effects of fluoxetine in dogs. Fluoxetine is an antidepressant belonging to a group of drugs called selective serotonin reuptake inhibitors (SSRI). Fluoxetine is used in dogs and cats for the treatment of canine aggression and obsessive-compulsive disorder. Fluoxetine requires a prescription from your veterinarian. Tablets are sold individually.

Uses/benefits of Cost Of Prozac For Dogs

For dogs with mild anxiety, Dr. Pike recommends natural calming pheromones and supplements. These include the Adaptil pheromone spray or collar and Anxitane S which is an L- theanine supplement that comes in a chewable treat.

For dogs with more intense anxiety, she recommends Prozac (fluoxetine). Lexapro or Zoloft are other name brand psychotropic medications that are commonly used. There is also an FDA-approved version of Fluoxetine specifically made for dogs called Reconcile. Dr Pike likes this version because it comes in a flavored chew tab that most dogs will take as a treat.

(And, yes, you can use your SingleCare card on any drugs that your vet prescribes that would also be prescribed to a human—i.e., Prozac, Lexapro—for savings up to 80%).

Dosage Of Fluoxetine For Dogs

Dosage of fluoxetine for dogs will vary based on the condition that needs treatment, the size of the dog, and the dog’s response to the drug. It’s important to follow your veterinarian’s instructions closely, as overdose of fluoxetine can cause seizures in dogs.

Typically the drug is given in a dosage of 0.5 to 0.9 mg per pound orally once per day. So, for example, a 30-pound dog would probably get somewhere between 15 and 27 mg per day.

Fluoxetine usually comes in 10 mg or 20 mg tablets, and your vet will let you know how to give a precise dose.


Avoid giving other medicines that can make your pet sleepy (cold or allergy medicine, pain medication, muscle relaxants, seizure medicine, or other medications for depression or anxiety). Do not give Reconcile if your pet is using an MAO inhibitor such as Anipryl, selegiline, Preventic Collar, or Mitaban Dip. Side effects that may occur include rash, hives, difficulty breathing, or swelling of the face, lips, tongue, or throat. If these or any other side effects occur, stop giving your pet Fluoxetine and contact your veterinarian.

Fluoxetine Side Effects

  • Dogs: Sedation and anorexia are the most-commonly reported side effects. Other side-effects include GI upset and behavior changes (anxiety, irritability, hyperactivity, and insomnia). Aggression (very uncommon) and seizures also have been reported.
  • Cats: Anorexia and behavior changes (anxiety, irritability, hyperactivity/insomnia, and elimination behavior) are the most-commonly reported side effects in cats. Anorexia is a common-enough side effect in the cat that the client should monitor the cat’s appetite and weight. Dermatitis may occur at the site of transdermal application.

Prices of Cost Of Prozac For Dogs

$9.95 – $29.99

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