Dexamethasone Injectable is for the treatment of primary bovine ketosis and as an anti-inflammatory agent in bovine and equine. As supportive therapy, Dexamethasone Injection 2 mg/mL may be used in the management of various rheumatic, allergic, dermatologic, and other diseases known to be responsive to anti-inflammatory corticosteroids. Dexamethasone Injection 2 mg/mL may be used intravenously as supportive therapy when an immediate hormonal response is required.
Description
Dexamethasone is a synthetic corticosteroid with approximately 25 times the anti-inflammatory potency of naturally occurring cortisol. Corticosteroids such as dexamethasone are important in normal protein, carbohydrate and fat metabolism, and for their role in controlling inflammation. These drugs have both strong beneficial effects and a definite potential to cause negative side-effects. Dexamethasone commonly is used in both small- and large-animal veterinary medicine. It may be given by injection, inhalation, orally, or topically. Preparations for topical use may include other active ingredients such as antibiotics, antifungals, or miticides.
Uses/benefits of Dexamethasone For Cattle
Bovine Ketosis
DEXAMETHASONE INJECTION 2 mg/mL is offered for the treatment of primary ketosis. The gluconeogenic effects of DEXAMETHASONE INJECTION 2 mg/mL, when administered intramuscularly, are generally noted within the first 6 to 12 hours. When DEXAMETHASONE INJECTION 2 mg/mL is used intravenously, the effects may be noted sooner. Blood sugar levels rise to normal levels rapidly and generally rise to above normal levels within 12 to 24 hours. Acetone bodies are reduced to normal concentrations usually within 24 hours. The physical attitude of animals treated with DEXAMETHASONE INJECTION 2 mg/mL brightens and appetite improves, usually within 12 hours. Milk production, which is suppressed as a compensatory reaction in this condition, begins to increase. In some instances, it may even surpass previous peaks. The recovery process usually takes from 3 to 7 days.
Supportive Therapy
DEXAMETHASONE INJECTION 2 mg/mL may be used as supportive therapy in mastitis, metritis, traumatic gastritis, and pyelonephritis, while appropriate primary therapy is administered. In these cases, the corticosteroid combats accompanying stress and enhances the feeling of general well-being.
DEXAMETHASONE INJECTION 2 mg/mL may also be used as supportive therapy in inflammatory conditions, such as arthritic conditions, snake bite, acute mastitis, shipping fever, pneumonia, laminitis, and retained placenta.
Equine
DEXAMETHASONE INJECTION 2 mg/mL is indicated for the treatment of acute musculoskeletal inflammations, such as bursitis, carpitis, osselets, tendonitis, myositis, and sprains. If boney changes exist in any of these conditions, joints, or accessory structures, responses to DEXAMETHASONE INJECTION 2 mg/mL cannot be expected. In addition, DEXAMETHASONE INJECTION 2 mg/mL may be used as supportive therapy in fatigue, heat exhaustion, influenza, laminitis, and retained placenta provided that the primary cause is determined and corrected.
Ingredients:
Each ml of Dexamethasone Injectable contains 2 mg dexamethasone, 500 mg polyethylene glycol 400, 9 mg benzyl alcohol, 1.8 mg methylparaben and 0.2 mg propylparaben as preservatives, 4.75% alcohol, HCl to adjust pH to approximately 4.9, water for injection q.s.
Administration And Dosage
Therapy with DEXAMETHASONE INJECTION 2 mg/mL, as with any other potent corticosteroid, should be individualized according to the severity of the condition being treated, anticipated duration of steroid therapy, and the animal’s threshold or tolerance for steroid excess.
Treatment may be changed over to DEXAMETHASONE INJECTION 2 mg/mL from any other glucocorticoid with proper reduction or adjustment of dosage.
Bovine –DEXAMETHASONE INJECTION 2 mg/mL – 5 to 20 mg intravenously or intramuscularly.
Dexamethasone Powder may be administered or the parenteral dose repeated as needed.
Equine –DEXAMETHASONE INJECTION 2 mg/mL – 2.5 to 5 mg intravenously or intramuscularly.
Dexamethasone Powder may be administered or the parenteral dose repeated as needed.
Prices of Dexamethasone For Cattle
$25.20 – $245.00