Excenel RTU EZ Sterile Suspension is a broad spectrum injectable antibiotic indicated for the treatment of bovine respiratory disease (BRD, shipping fever, pneumonia), foot rot, and acute metritis in cattle, and for the treatment/control of swine bacterial respiratory disease (SRD) in swine. Each ml of Excenel RTU EZ contains ceftiofur hydrochloride equivalent to 50 mg ceftiofur. For intramuscular and subcutaneous injection in cattle. For intramuscular injection in swine. Excenel RTU EZ may be used in lactating dairy cattle. Ready-to-use suspension. Shake well before using. Ceftiofur.
To improve ease of use, Excenel RTU EZ is a lower viscosity formulation that improves syringeability. It requires only 60 percent of the force needed to administer the previous formula, particularly beneficial during colder weather.
Features of Excenel For Sheep
EXCENEL contains the sodium salt of ceftiofur which is a broad spectrum cephalosporin antibiotic active against Gram-positive and Gram-negative bacteria including β-lactamase-producing strains. Like other cephalosporins, ceftiofur is bactericidal in vitro as a result of inhibition of cell wall synthesis.
Medicinal Ingredient: Each mL of reconstituted solution contains 50 mg ceftiofur (as ceftiofur sodium).
Preservative: Benzyl Alcohol 9 mg per mL (in the sterile diluent)
Non-medicinal ingredients:
Sterile Water for injection, 1 qs per mL
Monobasic Potassium Phosphate, 1.388 mg per mL
Sodium hydroxide, 10% qs to pH
Indication:
- Cattle: For treatment of bovine respiratory disease (shipping fever, pneumonia) associated with Mannheimia haemolytica, Pasteurella multocida and Haemophilus somnus. For the treatment of acute bovine interdigital necrobacilosis (foot rot, pododermatitis) associated with Fusobacterium necrophorum and Bacteroides melaninogenicus.
- Horses: For treatment of respiratory infections in horses associated with Streptococcus zooepidemicus.
- Lambs: For treatment of respiratory disease (pneumonia) in lambs associated with Mannheimia haemolytica.
- Dogs: For the treatment of canine urinary tract infections associated with Escherichia coli and Proteus mirabilis.
Administration & Dosage:
- Reconstitute with 20 ml of sterile diluent.
- Cattle: 1 mg/kg BW (1 ml/50 kg BW) IM, ever 24 hours thrice. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments.
- Horses: 2 mg/kg BW (2 ml/50 kg BW) IM, every 24 hours twice. If no response is observed within 4 – 5 days, the diagnosis should be re-evaluated.
- Lambs: 2 mg/kg BW, IM, every 24 hours thrice. Additional treatments may be given on days four and five for animals which do not show a satisfactory response (not recovered) after the initial three treatments.
- Dogs: 2 mg/kg BW (0.2 ml/5 kg BW) IM, every 24 hours for 5 – 14 days.
Mode of Action of Excenel For Sheep
Ceftiofur sodium has demonstrated excellent in vitro and in vivo activity against Mannheimia haemolytica and Pasteurella multocida, two of the major pathogenic organisms associated with bovine respiratory disease (pneumonia, shipping fever). This drug has also demonstrated excellent in vitro and in vivo activity against Histophilus somni (Haemophilus somnus) and in vitro activity against Corynebacterium pyogenes, two other bacterial pathogens associated with bovine respiratory disease (BRD). Ceftiofur has demonstrated in vivo and in vitro activity against Fusobacterium necrophorum and Bacteroides melaninogenicus, two of the major pathogenic anaerobic bacteria associated with acute bovine interdigital necrobacillosis (foot rot, pododermatitis). Ceftiofur has excellent in vitro activity against Gram-negative pathogens such as Actinobacillus pleuropneumoniae, Salmonella choleraesuis, Pasteurella multocida and the Gram-positive pathogen Streptococcus suis, all of which singly or in combination can be associated with swine bacterial respiratory disease (swine bacterial pneumonia). Ceftiofur has also demonstrated excellent in vitro and in vivo activity against respiratory pathogens of horses.
The drug was very active in vitro against Streptococcus zooepidemicus, S. equi, Streptococcus spp. and Pasteurella spp. isolated from patients with infections. Ceftiofur has demonstrated in vitro and in vivo activity against Mannheimia haemolytica, the major pathogenic bacterium associated with ovine respiratory disease (pneumonia). Ceftiofur has also demonstrated in vivo and in vitro activity against bacterial pathogens from dogs with urinary tract infections. Ceftiofur was more potent (in vitro) than other beta-lactam antibiotics against strains of Escherichia coli and Proteus mirabilis. In addition, ceftiofur has excellent in vitro activity against other Gram-negative pathogens, such as Proteus vulgaris, Klebsiella pneumoniae, Salmonella typhimurium and some in vitro action against certain strains of Gram-positive pathogens such as Staphylococcus aureus, Staphylococcus xylosus, Staphylococcus simulans, Staphylococcus epidermidis, Streptococcus uberis and Streptococcus bovis. The clinical significance of these findings is not known. Clinical efficacy for the treatment of bovine respiratory disease has been demonstrated on the basis of well controlled multi-location clinical trials involving large numbers of cattle. Ceftiofur sodium has demonstrated in vitro and in vivo activity against E. coli.
Prices of Excenel For Sheep
$94.99 – $243.99