Itraconazole is an antifungal agent that is used by veterinarians to treat a range of infections. Itraconazole/DMSO eye drops and ophthalmic ointment are used to treat ulcerative keratomycosis of horses, which means an ulcer of the cornea of the eye caused by a fungal infection. This medication is effective only against fungal infections and will be ineffective if used to treat other types of infections, such as those caused by parasites, bacteria, or viruses.

Topical itraconazole can kill the infective fungus at the concentrations that are reached on the surface of the eye. It is particularly effective against Aspergillus, one of the more-common fungal pathogens. The ophthalmic preparation of itraconazole contains 1% itraconazole, 30% DMSO, and artificial tears. This formulation is necessary because itraconazole does not dissolve well in water but dissolves well in DMSO. Itraconazole for dogs is an antifungal medication that treats a variety of infections. It’s most commonly prescribed to treat ringworm and cryptococcosis, a serious condition that affects the respiratory and nervous systems. Because itraconazole is typically a long-term treatment, it’s important for pet parents to understand how it works. Keep reading to learn more about the recommended dosages, efficacy, side effects, and drug interactions associated with itraconazole.


Itraconazole (brand names: Itrafungol®, Sporanox®, Onmel®) is a systemic antifungal medication used to treat fungal infections such as ringworm and blastomycosis. Its use in dogs, small mammals, and some exotics to treat fungal infections is ‘off label’ or ‘extra label’. Use of the human version of this drug is ‘off label’ or ‘extra label’ in both cats and dogs. Many drugs are commonly prescribed for off label use in veterinary medicine. In these instances, follow your veterinarian’s directions and cautions very carefully as their directions may be significantly different from those on the label.

Features of Itraconazole For Dogs

  • Itraconazole, known as by the names Sporanox®, Intrafungol®, Onmel®, is an antifungal drug used in dogs and cats to inhibits the growth of fungal organisms by interfering with the formation of the fungal cell wall. It is similar in its action to other related drugs, such as miconazole, fluconazole and ketoconazole (Nizoral®).
  • Itraconazole is classified as a synthetic oral triazole antifungal drug. It can be used to treat skin infections as well as generalized systemic infections.
  • Itraconazole is effective only against fungal or yeast organisms. These fungi are the ones that cause skin infections (dermatophytes) commonly known as “ringworm” and toenail infections. However, it also is effective for some more serious fungal infections, such as blastomycosis and cryptococcosis. These infections can affect the brain, bone, and respiratory tract (lungs).
  • Itraconazole is a prescription drug and can only be obtained from a veterinarian or by prescription from a veterinarian.
  • This drug is not approved for use in animals by the Food and Drug Administration but it is prescribed legally by veterinarians as an extra-label drug.

Dosing Information of Itraconazole for Dogs and Cats

  • Medication should never be administered without first consulting your veterinarian.
  • In dogs, the usual dose is 2.5 mg to 5 mg per pound (5 to 10 mg/kg) one to two times per day orally.
  • The dose for cats is 2.5 to 5 mg per pound (5 to 10 mg/kg) every 12 to 24 hours. It is common for fungal infections to require several weeks of treatment.
  • Itraconazole should be given with food.
  • The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. Be certain to complete the prescription unless specifically directed by your veterinarian. Even if your pet feels better, the entire treatment plan should be completed to prevent relapse or prevent the development of resistance.

Side effects of Itraconazole For Dogs

Side effects associated with itraconazole are rare, but may indicate liver toxicity. Consult your vet immediately if you notice any of the following symptoms:

  • Nausea
  • Vomiting
  • Diarrhea
  • Jaundice
  • Loss of appetite


  • Drug Name: Itraconazole
  • Common Name: Sporanox®
  • Drug Type: Antifungal
  • Used For: Fungus or yeast infections
  • Species: Dogs, Cats
  • Administered: 100 mg capsules, Oral liquid
  • FDA Approved: No

Prices of Itraconazole For Dogs

$47.49 – $121.58

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