Penicillin Injectable is a suspension of penicillin G procaine in 100, 250, and 500 mL multiple dose vials. Each mL is designed to provide 300,000 units of penicillin G as procaine in a stable suspension. Penicillin G procaine is an antibacterial agent which has activity against a variety of pathogenic organisms, mainly in the Gram-positive category.

Penicillin Injectable is indicated for treatment of bacterial pneumonia (shipping fever) caused by Pasteurella multocida in cattle and sheep, erysipelas caused by Erysipelothrix rhusiopathiae in swine, and strangles caused by Streptococcus equi in horses.


Dura-Pen Dual Penicillin by Durvet contains Penicillin G Procaine and Penicillin G Benzathine for treatment of bacterial infections in beef cattle due to penicillin susceptible organisms. This fast acting dual penicillin quickly raises blood levels against gram positive organisms and maintains therapeutic levels for a full 48 hours leading to quick resolution of the cattle’s respiratory condition. Conditions treated with Dura-Pen Dual Penicillin antibiotic are…

  • -Bacterial Pneumonia (shipping fever complex)
  • -Rhinitis, Pharyngitis or Blackleg.

Administer 2 ml per 150 lb. body weight to beef cattle SQ only with a subsequent dose in 48 hours. Treatment with dual action penicillin should be limited to a total of 2 doses given SQ and should not be used in lactating dairy cattle.  This product must be refrigerated and is available in two easy-to-use sizes: 100cc & 250cc.

Uses/benefits of Penicillin For Cattle

  • Combines long acting Penicillin G Procaine and Penicillin G Benzathine.
  • Broad spectrum of activity.
  • Easy syringe-ability because its non-foaming.
  • Single treatment maintains 48-hour penicillin levels.
  • Efficient and economical – reduces time, labor, and stress on animal associated with frequent injections.


  • Store between 2°C-8°C (36°F-46°F) and protect from freezing.
  • Warm to room temp and shake well prior to use.
  • Subcutaneous injection only.
  • Not for use in lactating dairy cattle.
  • Treatment should be limited to two doses given subcutaneously.

Features of Penicillin For Cattle

The penicillins, particularly the β-lactam ring, are somewhat unstable, being sensitive to heat, light, extremes in pH, heavy metals, and oxidizing and reducing agents. Also, they often deteriorate in aqueous solution and require reconstitution with a diluent just before injection. Penicillins are poorly soluble, weak organic acids administered parenterally either as suspensions in water or oil or as water-soluble salts. For example, sodium or potassium salts of penicillin G are highly water soluble and are absorbed rapidly from injection sites, whereas organic esters in microsuspension such as procaine penicillin G or benzathine penicillin G are gradually absorbed over 1–3 (or even more) days, respectively. The trihydrate forms of the semisynthetic penicillins have greater aqueous solubility than the parent compounds and are usually preferred for both parenteral and oral use.

The β-lactam nucleus that characterizes penicillins, when cleaved by a β-lactamase enzyme (penicillinase), produces penicilloic acid derivatives that are inactive but may act as the antigenic determinants for penicillin hypersensitivity. Modification of the 6-aminopenicillanic acid nucleus, either by biosynthetic or semisynthetic means, has produced the array of penicillins used clinically. These differ in their antibacterial spectra, pharmacokinetic characteristics, and susceptibility to microbial enzymatic degradation.

Directions For Use

A thoroughly cleaned, sterile needle and syringe should be used for each injection (needles and syringes may be sterilized in boiling water for 15 minutes). Before withdrawing the solution from the bottle, disinfect the rubber cap top with 70% alcohol. The injection site should be similarly disinfected with alcohol. Needles of 16 to 18 gauge and 1 to 1.5 inches long are adequate for intramuscular injections.

In livestock intramuscular injections should be made by directing the needle of suitable gauge and length into the fleshy part of a thick muscle, such as rump, hip, or thigh region; avoid blood vessels and major nerves. Before injecting the solution, pull back gently on the plunger. If blood appears in the syringe, a blood vessel has been entered; withdraw the needle and select a different site.


Penicillin Injectable is administered by the intramuscular route. The product is ready for injection after warming the vial to room temperature and shaking to ensure a uniform suspension.

The daily dose of penicillin is 3,000 units per pound of body weight (1 mL per 100 lbs body weight). Continue daily treatment until recovery is apparent and for at least one day after symptoms disappear, usually in two to three days.

Treatment should not exceed four consecutive days.

No more than 10 mL should be injected at any one site. Rotate injection sites for each succeeding treatment.

Care of Sick Animals:

The use of antibiotics in the management of diseases is based on an accurate diagnosis and an adequate course of treatment. When properly used in the treatment of diseases caused by penicillin-susceptible organisms, most animals treated with Penicillin Injectable show a noticeable improvement within 24 to 48 hours. If improvement does not occur within this period of time, the diagnosis and course of treatment should be re-evaluated. It is recommended that the diagnosis and treatment of animal diseases be carried out by a veterinarian.

Since many diseases look alike but require different types of treatment, the use of professional veterinary and laboratory services can reduce treatment time, costs and needless losses. Good housing, sanitation and nutrition are important in the maintenance of healthy animals and are essential in the treatment of disease.

Prices of Penicillin For Cattle

$69.00 – $139.00

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