Piperazine is the only FDA approved dewormer for use in laying hens in the United States. It is only effective against the adult large roundworm. It has no effect on any other species of worms, including tapeworms. Piperazine can be given orally by mouth in each bird, or added to the flock’s water source. Treatment needs to be repeated in 7-10 days since the drug does not kill the large roundworm eggs. If given by mouth: 50 mg/bird (if younger than 6 weeks of age), otherwise 100 mg/bird (if older than 6 weeks of age), or according to the manufacturer label. Repeat in 7-10 days. If added to flock water source: 3 mL per gallon of water, or in accordance with the manufacturer’s label. Repeat in 7-10 days.

Egg Withdrawal Period: In Australia and Canada, piperazine is approved for 1-time use in egg laying hens at doses ranging from 130 to 200 mg/kg (59 to 91 mg/lb) with a 0-day egg withdrawal. Storage/Stability: Unless otherwise specified by the manufacturer, piper­azine products should be stored at room temperature (15-30°C). Caution: Acute massive overdosage can lead to paralysis and death, but the drug is generally considered to have a wide margin of safety. The oral LD50 of piperazine adipate in mice is 11.4 g/kg.


Piperazine is an anthelmintic with activity against nematodes. It induces a reversible flaccid paralysis in the nematode parasites. This is provoked by hyperpolarisation of the cell membrane followed by suppression of spontaneous spike potentials. The paralysed nematodes are subsequently expelled from the gut lumen by normal peristaltic actions.

Side effects

Overdoses can cause colic, coughing, excessive salivation, excitation, hyperpnoea, lachrymation, spasms, sweating and vomiting.


  • Poultry. Dosage per 100 birds
    • Under 7 weeks of age: 42mL Piperazine in 2L water
    • 7 – 8 weeks of age: 56mL Piperazine in 2L water
    • 9 – 12 weeks of age: 56mL Piperazine in 4L water
    • 13 – 16 weeks of age: 56mL Piperazine in 6L water
    • 17 – 20 weeks of age: 80mL Piperazine in 10L water
    • Over 20 weeks of age: 80mL Piperazine in 10.5L water.
    • Provide according to number of birds in pen. When medicated water is consumed provide water for remainder of day. Do not provide plain water until medicated water is consumed. For use in wet mash: Mix according to dose rate table with sufficient water to prepare mash.
  • Pigeons: 20 mL product added to 1 L of water for one day. Depending o the severity of the infection birds may be wormed monthly. Do not provide plain water until medicated water is consumed. Repeat every 3-4 months.
  • Read the product label for specific detail on dosage.

Uses/benefits of Piperazine Citrate For Chickens

It is used against:

  • Poultry: Roundworms (Ascaridia galli)
  • Pigs: Roundworms (Ascaris suum) and nodular worms (Oesophagostomum spp)
  • Pigeons: Roundworms (Ascaridia columbae)
  • Cage birds: Roundworms (Ascaridia spp)

Withdrawal Period:

  • Meat : 3 days
  • Eggs : 2 days

Not authorised for use in animals producing milk for human consumption.

Prices of Piperazine Citrate For Chickens

$20.00 – $29.70

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