Procaine and benzathine penicillin G are small-spectrum penicillins with a bactericidal action against Gram-positive and Gram-negative bacteria like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase negative Staphylococcus and Streptococcus spp. After intramuscular administration within 1 to 2 hours therapeutic blood levels are obtained. Because of the slow resorption of benzathine penicillin G, the action is maintained for two days.
Penicillin G Procaine Injectable Suspension is available in 100-mL, 250-mL and 500-mL multiple dose vials. Each mL contains: penicillin G procaine 300,000 units, methylparaben 1.3 mg, propylparaben 0.2 mg, sodium citrate 10 mg, sodium carboxymethylcellulose 1 mg, povidone 5 mg, lecithin 6 mg, sodium formaldehyde sulfoxylate 0.2 mg, procaine hydrochloride 20 mg, in Water for Injection, q.s.
Indications
Arthritis, mastitis and gastrointestinal, respiratory and urinary tract infections caused by penicillin sensitive micro-organisms, like Campylobacter, Clostridium, Corynebacterium, Erysipelothrix, Haemophilus, Listeria, Pasteurella, penicillinase-negative Staphylococcus and Streptococcus spp. in calves, cattle, goats, sheep and swine.
Dosage
For intramuscular administration:
Cattle : 1 ml per 20 kg body weight.
Calves, goats, sheep and swine : 1 ml per 10 kg body weight.
This dosage can be repeated after 48 hours when necessary.
Note: Shake well before use and do not administer more than 20 ml in cattle, more than 10 ml in swine and more than 5 ml in calves, sheep and goats per injection site
Direction for use:
Restricted Drug (Under California Law); Use Only as Directed. The suspension should be administered by deep intramuscular injection within the fleshy muscles of the hip, rump, round or thigh, or into the neck, changing the site for each injection. Do not inject subcutaneously, into a blood vessel, or near a major nerve.
Use a 16 or 18 gauge need, 1.5 inches long. The needle and syringe should be washed thoroughly before use. The needle and syringe should then be sterilized by placing in boiling water for 15 to 20 minutes.
The injection site should be washed with soap and water and painted with a germicide such as tincture of iodine or 70% alcohol. The product should then be administered by using the following procedure:
1) Warm the vial to room temperature and shake thoroughly to ensure uniform suspension.
2) Wipe the rubber stopper on top of the vial with a piece of absorbent cotton soaked in 70% alcohol.
3) Inject air into the vial for easier withdrawal.
4) After filling the syringe, make sure the needle is empty by pulling back the plunger of the syringe until a small air bubble appears. Then detach the needle from the syringe.
5) Insert the needle deep into the muscle, attach the syringe and withdraw the plunger slightly. If blood appears, withdraw the needle and insert it into a different location.
6) Inject the dose slowly. Do not massage the site of the injection.
7) Not more than 10 mL should be injected into one location.
Precautions
Intramuscular injection in cattle, sheep, and swine may result in a local tissue reaction which persists beyond the withdrawal period of 14 days (cattle), 9 days (sheep), or 7 days (swine). This may result in trim loss of edible tissue at slaughter. Allergic or anaphylactic reactions, sometimes fatal, have been known to occur in animals hypersensitive to penicillin and procaine. Such reactions can occur unpredictably with varying intensity. Animals administered penicillin G procaine should be kept under close observation for at least one half hour. Should allergic or anaphylactic reactions occur, discontinue use of the product and call a veterinarian. If respiratory distress is severe, immediate injection of epinephrine or antihistamine following manufacturer’s recommendations may be necessary.
As with all antibiotic preparations, use of this drug may result in overgrowth of nonsusceptible organisms, including fungi. A lack of response by the treated animal, or the development of new signs or symptoms suggest that an overgrowth of nonsusceptible organisms has occurred. In such instances, consult your veterinarian. It is advisable to avoid giving penicillin in conjunction with bacteriostatic drugs such as tetracyclines.
Withdrawal time
– For meat : 14 days.
– For milk : 3 days.
Prices of Procaine Penicillin For Goats
$25.55 – $56.99