Salmonellosis, also known as salmonella infection, is caused by a family of bacteria with thousands of members most of which can affect all species, and which infected animals can eliminate in a period of weeks. Salmonella dublin is one member which is species adapted to infect cattle and as such a carrier state exists. This means that once an animal is infected a high proportion fail to clear infection fully and will shed bacteria later in life in times of stress etc.

The other prevalent strain in Ireland is Salmonella typhimurium which can affect a wide range of species including man. The clinical consequences of infection are determined by the strain of bacteria, the immune resistance of the animal infected, and the number of bacteria taken in. Various strains have varying ability to cause mild or serious disease.

Features & Benefits

  • ENTERVENE-D is USDA approved as an aid in prevention of clinical disease due to Salmonella dublin.
  • ENTERVENE-D is available in 10-dose and 50-dose bottles.

Uses for Vaccination

  1. The passive immunity/protection of the calf afforded by the colostrum from a cow vaccinated during the dry period has been shown to be of value; usually killed (often autogenous) bacterins are used. This approach probably provides specific antibody to prevent colonization of the calf=s gut, and also some systemic antibody that may serve to protect the calf against the effects of endotoxin/LPS if the Salmonella were to become bacteremic. This sort of immunity could easily be overcome with an overwhelming challenge dose from the environment. This type of immunity also appears to be quite short lived (first week of life). See House, J et al “Prevention of Salmonellosis in Dairy Cattle” Proceedings 18th ACVIM, Seattle, WA 2000.
  2. Calves and adult cattle have been protected by vaccination with live attenuated vaccines against challenge with the same serogroup.


  • 2 mL dose, subcutaneous
  • Provide a booster dose at 12 to 16 days following the first vaccination


Control of salmonellosis is based on four equally important aspects:

Selective culling – Reduction of circulating bacteria can be achieved with the introduction of a vaccination program and progressive culling of those animals that are identified as a potential source of the bacteria. In most farms due to the high sero-prevalence it is not economically feasible to test and cull all the sero-positive animals. Furthermore the antibody test is not a highly reliable indicator of immune / exposure status.

Biosecurity – Maintaining biosecurity involves avoiding introduction of infected animals into the herd and/or implementing stict isolation / quarantine of introductions until proven negative, and restricting access of livestock to external sources of infection e.g. double fencing is in place at all perimeters, restricting access of visitors to the farm etc.

Vaccination – The use of vaccine is useful in reduction of the bacterial circulation, which has been proven in a study on S. typhimurium. For more on disease control through vaccination, contact your vet. Bovivac S is an inactivated vaccine for active immunisation of cattle to reduce the intensity and duration of the clinical signs induced by an infection with Salmonella dublin or S. typhimurium and to reduce excretion of S. typhimurium. For more information on the use of this vaccine, contact your vet.

Monitoring – This varies depending on the nature and risk status of your herd. Appropriate screening programs can be discussed with your local veterinary practitioner.

Prices of Salmonella Vaccine Cattle

$56.00 – $149.50

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