Tetrahydrofolic acid (THF) is a coenzyme in the synthesis of purine bases and thymidine. These are constituents of DNA and RNA and are required for cell growth and replication. Lack of THF leads to inhibition of cell proliferation. Formation of THF from dihydrofolate (DHF) is catalyzed by the enzyme dihydrofolate reductase. DHF is made from folic acid, a vitamin that cannot be synthesized in the body but must be taken up from exogenous sources. Most bacteria do not have a requirement for folate, because they are capable of synthesizing it – more precisely DHF from precursors. Selective interference with bacterial biosynthesis of THF can be achieved with sulfonamides and trimethoprim.
Triple Sulfa is indicated for use in case of infections (esp. respiratory and intestinal infections) caused by micro-organisms sensitive to sulfonamides. Including shipping fever, acute metritis, foot-rot, bacterial scours,haemorrhagic septicaemia, wooden tongue, strangles, infectious coryza, acute fowl cholera, pullorum typhoid disease and coccidiosis.
Administration in case of renal or hepatic insufficiency, chronic infections, abscess formation, poultry laying eggs and prolonged administration (longer than 7 days).
Continued use in ruminants may result in diarrhoea and debility with a loss of appetite and milk yield.
In poultry, depression, retarded growth and haemorrhages may occur. Sometimes egg production is reduced with thin and/or rough shells. In all animal species crystalluria may occur, but this is rare due to the combination of three sulfonamides.
Dosage and Administration
To reduce the development of antimicrobial resistance and maintain effectiveness, use this antibiotic prudently and for the shortest duration required to achieve the desired clinical outcome.
Prevention: When birds are moved to an area where they will be more susceptible to contact with the disease, mix 30 mL of Sulfa-Q with 20 L of drinking water. Give this medication for 2 consecutive days, then stop treatment for 3 days. If necessary, repeat the treatment until all dangers of infection are gone.
Treatment: When clinical signs of coccidiosis are first observed, mix 30 mL of Sulfa-Q with 20 L of drinking water and give to birds for 2 consecutive days; then for the next three days give water without medication. Continue this treatment for 2 days out of 5 and repeat until all clinical signs of the disease have disappeared. During the treatment, medicated water should be the only source of drinking water.
For automatic proportioner: Set the apparatus to distribute 30 mL of stock solution per 4 L of drinking water (1 oz/U.S. gallon). Prepare a stock solution by adding 1 L of Sulfa-Q to 4 L of water. This will medicate approximately 666 L of drinking water. Mix thoroughly.
Features of Sulfa For Chickens
- For all classes of poultry
- Boosts the immune system corrects Vitamin deficiencies improves antibiotic response
- Helps appetite poor hatchability eases shipping strain and heat stress
- Provides more growth reproduction & resistance to disease
- Age range description: All Life Stages
Uses/benefits of Sulfa For Chickens
Mechanism of action
Sulfonamides structurally resemble p-aminobenzoic acid (PABA), a precursor in bacterial DHF synthesis. As false substrates, sulfonamides competitively inhibit utilization of PABA, and hence DHF synthesis. Because most bacteria cannot take up exogenous folate, they are depleted of DHF
Prices of Sulfa For Chickens
$17.98 – $37.99