Di-Methox Concentrated Solution contains 12.5% sulfadimethoxine for treatment of shipping fever, pneumonia, calf diphtheria, and foot rot. Di-Methox is for oral use in cattle (except dairy cows), chickens, and turkeys. Add to the drinking water for up to 5 days. Usual cattle dosage is 1 gallon per 200-400 gallons of drinking water. Sulfadimethoxine.


In cattle, Sulfadimethoxine Injection 40% is an effective treatment of bacterial pneumonia, shipping fever complex, calf diphtheria, and foot rot. Sulfadimethoxine has been demonstrated clinically or in the laboratory to be effective against a variety of organisms, such as streptococci, klebsiella, proteus, shigella, staphylococci, E. coli, salmonella and fusobacterium.

Broad coverage of treatments:

Shipping Fever Complex

Bacterial Pneumonia

Calf Diphtheria

Foot Rot

Low dosage, quick acting

Approved for lactating dairy cows, beef cattle, and ruminating calves

Uses/benefits of Sulfadimethoxine For Cattle

– Rapid penetration – effective blood and tissue levels reaches rapidly
– Fast-acting – works fast because it’s not inactivated by minerals in drinking water
– Highly palatable – high palatability assures animals receive the entire dosage


During treatment period, make certain that animals maintain adequate water intake.

If animals show no improvement within 2 or 3 days, consult your veterinarian.

Tissue damage may result from perivascular infiltration.

Dosage and Administration

Sulfadimethoxine Injection 40% must be administered only by the intravenous route in cattle. Cattle should receive 1 mL of Sulfadimethoxine Injection 40% per 16 pounds of body weight (55 mg/kg) as an initial dose, followed by 0.5 mL per 16 pounds of body weight (27.5 mg/kg) every 24 hours thereafter. Sulfadimethoxine boluses may be utilized for maintenance therapy in cattle. Representative weights and doses are indicated in the following table

Each mL contains 400 mg sulfadimethoxine:

Animal WeightInitial Dose25 mg/lb (55 mg/kg)Subsequent Daily Doses12.5 mg/lb (27.5 mg/kg)
200 lb (113.6 kg)15.6 mL7.8 mL
500 lb (227.2 kg)31.2 mL15.6 mL
750 lb (340.9 kg)46.9 mL23.5 mL
1000 lb (454.5 kg)62.5 mL31.3 mL

Prices of Sulfadimethoxine For Cattle

$56.95 – $96.99

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