Tetracycline has a wide range of antibacterial activity. It interferes with the formation of a complex between the transport RNA and the ribosome, which leads to a violation of protein synthesis by a microbial cell. Active in relation to most gram-positive and gram-negative bacteria, spiophets, leptospires, rickettsiaes, trachomae pathogens, ornithosis, and large viruses.
Description
Tetracycline – an antibiotic. It has a bacteriostatic effect by suppressing the synthesis of protein pathogens. It is indicated for infectious and inflammatory diseases caused by microorganisms sensitive to tetracycline, including Pneumonia, bronchitis, pleural empyema, angina, cholecystitis, pyelonephritis, intestinal infections, endocarditis, endometritis, prostatitis, syphilis, gonorrhea, brucellosis, rickettsiosis, purulent infections of soft tissues, osteomyelia; Trachoma, conjunctivitis, blepharitis; Eels. It is used for prevention of postoperative infections.
Indication:
- Infectious Coryza, Fowl Cholera, Fowl Typhoid, Chronic Respiratory Disease, Spirochaetosis, Bacillary White Diarrhoea, Psittacosis (ornithosis).
- To prevent infections during stress periods following vaccinations, sudden change of weather, exposure to extreme temperatures and movement or transport of birds.
- To prevent early chick mortality, to stimulate appetite and fasten growth
Side effects
On the part of digestive system: nausea, vomiting, anorexia, abdominal pain, diarrhea, constipation, dry mouth, glossitis, discoloration of the tongue, esophagitis, transient increase in hepatic transaminase activity, alkaline phosphatase, bilirubin concentration, residual nitrogen.
On the part of the central nervous system: dizziness, headache.
On the part of the hematopoiesis system: neutropenia, thrombocytopenia, hemolytic anemia.
On the part of allergic reactions: skin rash, itching, eosinophilia, Quincke’s edema.
On the part dermatological reactions: photosensitization.
Effects due to chemotherapeutic action: candidal stomatitis, vulvovaginal candidiasis, intestinal dysbiosis.
On the part of local reactions: soreness in the injection site.
Other effects: hypovitaminosis of vitamins of group B / A.
Mechanism of action:
Tetracyclines inhibit bacterial protein synthesis. Their site of action is the bacerial ribosome – 30 S subunit, thereby preventing binding to those ribosomes of aminoacyl transfer-RNA. Active transport of the drug into the bacterial cell must occur in order for the drug to be effective. Doxycycline enters the cell by passive diffusion.
Adverse Effects and Toxicity:
Because several diverse effects may result from administration of tetracyclines, caution should be exercised. Superinfection by nonsusceptible pathogens such as fungi, yeasts, and resistant bacteria is always a possibility when broad-spectrum antibiotics are used. This may lead to GI disturbances after either PO or parenteral administration or to “persistent infection” when they are applied topically (eg, in the ear). Severe and even fatal diarrhea can occur in horses receiving tetracyclines, especially if the animals are severely stressed or critically ill.
High doses administered PO to ruminants seriously disrupt microfloral activity in the ruminoreticulum, eventually producing stasis. Elimination of the gut flora in monogastric animals reduces the synthesis and availability of the B vitamins and vitamin K from the large intestine. With prolonged therapy, vitamin supplementation is a useful precaution.
Prices of Tetracycline For Birds
$6.30 – $64.80